Macrophage Identity
Gene co-expression module in Macrophages
| Category | Innate immunity |
|---|---|
| Genes | 24 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 24 genes have a known function matching the annotation |
Why this annotation
Top hub genes include TLR7 and TLR6 (innate pattern recognition receptors), CSF1R (macrophage colony-stimulating factor receptor, core macrophage identity gene), MAF (transcription factor critical for macrophage differentiation), STAB1 (scavenger receptor expressed by tissue macrophages), MPEG1 (macrophage-expressed gene 1), and HLA-DOA (antigen presentation). CYSLTR1 and PLCB2 are involved in innate immune signaling. This module captures a macrophage identity and innate immune sensing program.
Genes
CCDC88B, CSF1R, CYP4V2, CYSLTR1, EVL, FAM53B, FOXRED2, GATM, GPR155, HLA-DOA, HLA-E, MAF, MPEG1, MPPE1, NUDT3, PAQR8, PLCB2, SLC46A1, SLC46A3, STAB1, TLR6, TLR7, TP53INP1, VASH1
Most correlated modules
- Resident Mac Niche · correlation 0.89
- Endosomal Membrane Trafficking · correlation 0.88
- Innate Antiviral Sensing · correlation 0.88
- Myeloid Signaling Regulation · correlation 0.86
- Efferocytosis Anti-inflammatory · correlation 0.84
- Macrophage Proliferation · correlation 0.83
- Cytoskeletal Migration · correlation 0.79
- Resident Mac Identity · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.