Inflammasome Pyroptosis
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
GSDMD (gasdermin D, pyroptosis executor) and IL18 (inflammasome-released cytokine) indicate inflammasome/pyroptosis activity. PLA2G2D (phospholipase A2) and PTGDS (prostaglandin D2 synthase) and ENPP2 (autotaxin, LPA production) indicate lipid mediator production. TIFAB (TRAF-interacting protein with forkhead-associated domain B, negative regulator of innate signaling), UBD (FAT10, ISG/ubiquitin-like), IL22RA2 (IL-22 decoy receptor, anti-inflammatory), LGALS2 (galectin-2), CSTA (cystatin A), HLA-DQB2. The module combines pyroptosis/inflammasome signaling with lipid mediator production. The dominant theme is inflammasome-associated inflammatory signaling in macrophages.
Genes
ARRDC1, ATOX1, CSTA, EMP2, ENPP2, FBXO6, GSDMD, HLA-DQB2, IL18, IL22RA2, LGALS2, OAZ2, PLA2G2D, PPA1, PTGDS, REPIN1, SNX20, TIFAB, TOR3A, TSPAN13, UBD
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.