PPA1 — Inorganic pyrophosphatase 1

PPA1 belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PPA1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Glycolysis OxPhos Mitochondrial & OxPhos	ATP5F1B, ENO1, MDH2, NDUFB2, PARK7, PRELID1, PSMA7, PSMB1 +1 more	View in SCUBA
CD4⁺ T cells	Nucleotide biosynthesis Housekeeping	CCT7, COPRS, DCTPP1, MRPL12, MRPL4, NHP2, NME1, PRDX4 +6 more	View in SCUBA
Endothelial	Hypoxia-IFN Endothelial Endothelial cell development	BCAM, CRIP2, EPAS1, FES, HEG1, IFI27, IFITM1, LIMA1 +8 more	View in SCUBA
Enterocytes	Core energy metabolism Mitochondrial & OxPhos	ACAA2, CFL1, CYCS, GAPDH, ME2, P4HB, PSME2, SOD1	View in SCUBA
Fibroblasts	Immunoproteasome MHC-I Inflammatory	B2M, BST2, EPSTI1, HLA-A, HLA-B, HLA-C, HLA-F, IFI27 +7 more	View in SCUBA
Gamma-delta T cells	Mitochondrial OxPhos Mitochondrial & OxPhos	ADSL, AP1S1, CD151, COMTD1, COX5A, DDT, DNPH1, DUSP23 +20 more
Glial cells	IFN-gamma Effector Program Inflammation	APOL1, APOL2, GBP1, IDO1, IFI44L, IL18BP, IL32, LAP3 +5 more	View in SCUBA
Goblet cells	Mucosal Innate Defense Immune function	BOLA3, CTSS, DMBT1, ENO1, GPI, LGALS3BP, OLFM4, PIGR +4 more	View in SCUBA
Hematopoietic progenitor cells	Metabolic Housekeeping Housekeeping	CRYGD, EBPL, HINT1, HSPB1, LSM7, PCBD1, TALDO1, YBX3
Innate lymphoid cells	ILC Survival Residency Gut residency	ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4 +25 more	View in SCUBA
Lymphatic endothelial	Hypoxia HIF Response Stress	AKR1C1, AKR1C2, AKR1C3, ATP1A1, BNIP3, CARHSP1, CSRP2, CTSS +4 more	View in SCUBA
Macrophages	Inflammasome Pyroptosis Inflammatory	ARRDC1, ATOX1, CSTA, EMP2, ENPP2, FBXO6, GSDMD, HLA-DQB2 +12 more	View in SCUBA
Monocytes	IFN-γ Monocyte Response Inflammatory	ANKRD22, APOL3, ATF5, CXCL9, HAPLN3, IL2RA, IL2RG, LYSMD2 +2 more	View in SCUBA
Mucosal-associated invariant T cell	Antigen Processing Protein processing & ER	AQP3, ATP5MJ, CAPNS1, CCDC107, CTDNEP1, NCR3, NSA2, PHB2 +8 more
Smooth muscle cells	IFN-gamma/NF-kB Response Inflammation	ATP6V0B, CCDC71L, CFLAR, CHI3L2, EVA1B, GBP1, GBP2, HSPA8 +11 more	View in SCUBA

About the gene

Synonyms	IOPPP, PP, PP1, Ppase, SID6-8061
Chromosome	10: 70202835-70233911
Predicted location	Intracellular
Essential gene	Yes
Protein class	Enzymes, Essential proteins, Metabolic proteins, Predicted intracellular proteins
Molecular function	Hydrolase

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.