PTGDS — Prostaglandin D2 synthase
PTGDS belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTGDS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Myeloid Contamination Cell contamination | BASP1, C7, CARMIL1, CCL23, CH25H, CSRP2, CTSC, DENND2D +20 more | View in SCUBA |
| Fibroblasts | Complement-producing Fibroblast Inflammatory | ANK2, C3, CLSTN3, CYP7B1, DAAM1, DHRS3, GUCY1A1, GUCY1B1 +8 more | View in SCUBA |
| Gamma-delta T cells | Tissue-resident gd T Tissue residence | AKR1C3, ASCL2, BFSP1, CARNS1, CD320, CES1, CMKLR1, CTBP2 +21 more | |
| Macrophages | Inflammasome Pyroptosis Inflammatory | ARRDC1, ATOX1, CSTA, EMP2, ENPP2, FBXO6, GSDMD, HLA-DQB2 +12 more | View in SCUBA |
| Mucosal-associated invariant T cell | NK-like Cytotoxic cytotoxicity | AKR1C3, BNC2, CLIC3, CX3CR1, FCGR3A, FGFBP2, GNLY, IGFBP7 +3 more | |
| Natural Killer cells | KIR+ NK Maturation Immune regulation | AXIN1, ENC1, FAM53B, GTF3C1, KIR2DL1, KIR2DL3, KIR3DL1, KIR3DL2 +3 more | View in SCUBA |
| Smooth muscle cells | Stromal Chemokine Secretion Inflammation | C7, CCL19, CCL2, CCL21, CH25H, CXCL12, CXCL2, LINC00924 +9 more | View in SCUBA |
About the gene
| Synonyms | L-PGDS, PGDS |
|---|---|
| Chromosome | 9: 136975092-136981742 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Isomerase |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Mast cell degranulation, Prostaglandin biosynthesis, Prostaglandin metabolism, Transport |
Function
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non- substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.