ATOX1 — Antioxidant 1 copper chaperone

ATOX1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ATOX1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	OxPhos & redox Mitochondrial & OxPhos	CHCHD2, HNRNPR, KIF5B, MRPS21, NDUFAB1, NDUFB1, NDUFB2, POMP +5 more	View in SCUBA
Endothelial	ER Protein Processing Protein processing & ER	AP2S1, C1QBP, CCT3, DBI, ENO1, NHP2, OSTC, PPIB +5 more	View in SCUBA
Fibroblasts	Proteasome Assembly Housekeeping	C1QBP, DBI, DYNLT1, MANF, MRPL52, NDUFV2, PDCD5, PRELID1 +4 more	View in SCUBA
Gamma-delta T cells	Cytotoxic Effector Actin cytotoxicity	ARPC2, ARPC5, BRK1, CFL1, CLIC1, CORO1A, DBI, MYL12B +14 more
Glial cells	Proteostasis Stress Response Stress	ATP5MG, ATP6V0E1, C19orf53, C4orf3, COX7B, CYSTM1, GUK1, IFITM2 +7 more	View in SCUBA
Innate lymphoid cells	Mitochondrial OxPhos Biogenesis Mitochondrial & OxPhos	AP1S1, ATP5ME, ATP5MF, C1QBP, CNIH1, CYC1, ERH, HSD17B10 +22 more	View in SCUBA
Lymphatic endothelial	Oxidative Stress Response Stress	AP2S1, APRT, C4orf3, FKBP1A, GADD45GIP1, GSTP1, RABAC1, SH3BGRL3 +1 more	View in SCUBA
Macrophages	Inflammasome Pyroptosis Inflammatory	ARRDC1, CSTA, EMP2, ENPP2, FBXO6, GSDMD, HLA-DQB2, IL18 +12 more	View in SCUBA

About the gene

Synonyms	HAH1
Chromosome	5: 151742316-151772532
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	Chaperone
Biological process	Copper transport, Ion transport, Transport

Function

Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.