ENPP2 — Ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ENPP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Barrier Homeostasis migration & adhesion | AFDN, CD2AP, CLEC3B, IFNGR1, IL6R, ITGB4, JAM2, LIFR +11 more | View in SCUBA |
| Fibroblasts | Intestinal Fibroblast Identity Developmental | ABR, AFF3, ATP8A1, ATP9A, CAMK4, DSE, GLP2R, MRPS6 +7 more | View in SCUBA |
| Macrophages | Inflammasome Pyroptosis Inflammatory | ARRDC1, ATOX1, CSTA, EMP2, FBXO6, GSDMD, HLA-DQB2, IL18 +12 more | View in SCUBA |
About the gene
| Synonyms | ATX, PD-IALPHA, PDNP2 |
|---|---|
| Chromosome | 8: 119557086-119673453 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase |
| Biological process | Chemotaxis, Lipid degradation, Lipid metabolism |
Function
Secreted lysophospholipase D that hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Its major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin- sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (Probable). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3- phosphocholine (lyso-PAF).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.