UPR Secretory Stress
Gene co-expression module in Mast cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 23 genes have a known function matching the annotation |
Why this annotation
ENPP3 is a canonical mast cell surface marker (CD203c) used to identify mast cells and basophils. ERN1 (IRE1α) is the master UPR sensor. ERGIC3, SURF4, TRAM1 are ER/ERGIC components involved in secretory pathway. ATP2C1 (SPCA1) is a Golgi calcium pump critical for mast cell granule biogenesis. AP1B1 is a clathrin adaptor for vesicle sorting. G6PD and PGD are pentose phosphate pathway enzymes supporting NADPH production. RUNX2 is a transcription factor. The ER/secretory pathway genes (ERN1, ERGIC3, SURF4, TRAM1, ATP2C1) form a coherent UPR/secretory stress program in mast cells, consistent with the module's increase in UC inflammation and decrease with treatment.
Genes
Most correlated modules
- Integrin-Calcium Signaling · correlation 0.86
- ER-Mitochondria Homeostasis · correlation 0.85
- General Cellular Maintenance · correlation 0.85
- Immune Activation Signaling · correlation 0.83
- Mast Cell Transcription · correlation 0.76
- Post-transcriptional Regulation · correlation 0.73
- Intracellular Trafficking · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.