Chromatin & Ubiquitin Regulation
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 34 genes have a known function matching the annotation |
Why this annotation
This 34-gene module has moderate expression (~24% positive) and no disease association. Hub genes include IDE (insulin-degrading enzyme, peptide catabolism), ZMYND8 (chromatin reader, transcriptional regulation), BTBD2 (BTB domain, ubiquitin/protein quality control), WDR7 (WD-repeat, chromatin/splicing), RALGPS2 (Ral GEF, Ras signaling), PARVG (parvin, integrin-linked kinase complex), FBXW8 (F-box protein, SCF ubiquitin ligase), RNF44 (RING E3 ligase), ZKSCAN1 (zinc finger, transcription), USP34 (deubiquitinase), NCOA3 (nuclear receptor coactivator), PIK3CB (PI3K catalytic subunit beta), KMT2D (histone H3K4 methyltransferase), NTRK1 (TrkA, neurotrophin receptor). The module combines chromatin regulators (ZMYND8, KMT2D, ZKSCAN1, NCOA3), ubiquitin pathway (FBXW8, RNF44, USP34, BTBD2), and signaling (PIK3CB, RALGPS2, NTRK1). This is a broad transcriptional/epigenetic regulatory program without a tight single identity.
Genes
Most correlated modules
- Immune Activation Signaling · correlation 0.86
- Mast Cell Transcription · correlation 0.81
- Chromatin Epigenetic Regulation · correlation 0.81
- General Cellular Maintenance · correlation 0.79
- Intracellular Trafficking · correlation 0.78
- Integrin-Calcium Signaling · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.