NF-κB Stress Signaling
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
HSF1 is the master heat shock/stress transcription factor; TRAF6 and TAB2 are core NF-κB pathway adaptors downstream of innate immune receptors; IL6ST (gp130) is the shared IL-6 family cytokine receptor subunit; ITGAV is an integrin involved in stress and inflammatory signaling; TP53BP2 links to p53-mediated stress responses; PTPN1 (PTP1B) modulates cytokine receptor signaling; ARIH1 is a ubiquitin E3 ligase. The module is upregulated in both UC and CD inflammation. The convergence of HSF1, TRAF6/TAB2 (NF-κB), and IL6ST points to a stress-responsive inflammatory signaling program.
Genes
Most correlated modules
- ER Protein Quality Control · correlation 0.94
- Circadian Transcription · correlation 0.93
- Innate Immune Stress · correlation 0.92
- Ubiquitin-Chromatin Regulation · correlation 0.91
- Housekeeping Signaling · correlation 0.89
- Inflammatory IRAK3-BATF Response · correlation 0.89
- MARCH Ubiquitin Ligase · correlation 0.89
- LXR/PPAR Repression · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.