Telomere Maintenance
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include NECAP1 (clathrin-mediated endocytosis adaptor), TERF2 and TERF2IP (shelterin complex, telomere protection), POLK (translesion synthesis DNA polymerase), CCNK (cyclin K involved in transcription-coupled DNA repair), AKNA (AT-hook transcription factor), PRKD3 (protein kinase D), and ZBTB4 (transcriptional repressor). The TERF2/TERF2IP pair is a strong signal for telomere maintenance. POLK and CCNK add DNA repair context. The module is modestly reduced by UC treatment. This module reflects telomere integrity and DNA repair maintenance, a housekeeping-adjacent program.
Genes
Most correlated modules
- Transcription & Splicing · correlation 0.86
- Autophagy Stress Response · correlation 0.84
- Splicing & Transcription · correlation 0.84
- P-body mRNA Decay · correlation 0.81
- Mediator-Integrator Transcription · correlation 0.78
- Mitochondrial Respiratory Complex · correlation 0.77
- General Housekeeping · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.