Mitotic Spindle
Gene co-expression module in Mast cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 19 of 27 genes have a known function matching the annotation |
Why this annotation
This module is dominated by canonical mitotic cell cycle genes: CCNB1 (cyclin B1, G2/M), CENPF, KIF23, KNL1, NDC80, CENPE, CENPO, CENPN (kinetochore/centromere components), MAD2L1 (spindle assembly checkpoint), PTTG1 (securin), CDKN3 (CDK inhibitor at M-phase), KIF20B (kinesin, cytokinesis), BRCA1 (DNA repair/checkpoint), ATAD5 (DNA replication), FBXO5 (APC/C inhibitor), CIP2A (PP2A inhibitor, mitosis), MXD3 (proliferation TF), SAC3D1, POC1A (centriole). All top hub genes are core members. This is a tightly defined mitotic spindle/G2-M cell cycle module. Neighbor M146 also contains cell cycle genes (EZH2, CDK2, GMNN, NCAPG2), confirming this neighborhood represents proliferating mast cells.
Genes
Most correlated modules
- Mitotic Spindle · correlation 0.94
- S-phase DNA Replication · correlation 0.92
- FA DNA Repair · correlation 0.85
- Proliferation RNA Processing · correlation 0.85
- Chromatin Remodeling · correlation 0.83
- Mitotic Spindle · correlation 0.82
- OxPhos & RNA Processing · correlation 0.82
- S-phase Replication · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.