Mitotic Spindle
Gene co-expression module in Mast cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 32 genes have a known function matching the annotation |
Why this annotation
TACC3 stabilizes mitotic spindles. BUB3 is a spindle assembly checkpoint component. SMC1A is a cohesin subunit essential for sister chromatid cohesion. TMPO (LAP2) regulates nuclear envelope disassembly during mitosis. DEPDC1B promotes mitotic entry. RUNX1 is a hematopoietic/mast cell transcription factor also active in proliferating progenitors. ACTN1, LMO7, MYO1F are cytoskeletal. PIEZO1 is a mechanosensitive channel. ABCA7 is a lipid transporter. The module mixes mitotic machinery with cytoskeletal and mast cell identity genes, suggesting a proliferating mast cell progenitor state.
Genes
Most correlated modules
- Chromatin Remodeling · correlation 0.88
- SWI/SNF Remodeling · correlation 0.88
- DNA Replication · correlation 0.83
- Mitotic Spindle · correlation 0.82
- Mitotic Spindle · correlation 0.79
- Proliferation RNA Processing · correlation 0.79
- S-phase DNA Replication · correlation 0.79
- FA DNA Repair · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.