Mast Cell Transcription
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 14 of 25 genes have a known function matching the annotation |
Why this annotation
Top hub genes include MYB (master hematopoietic/mast cell transcription factor), multiple ZNF transcription factors (ZNF217, ZNF608, ZNF609), PHC1 (Polycomb repressive complex), MBD6 (methyl-CpG binding epigenetic regulator), MBNL1 (RNA splicing regulator), PTEN (PI3K pathway tumor suppressor), PRKACB (PKA signaling), INSR (insulin/growth factor receptor), and ITGB8 (integrin activating TGF-beta). The module shows the strongest UC inflammation upregulation of the batch (delta=0.767, sig.) with near-complete remission reversal. MYB is a critical regulator of mast cell development and identity. The convergence of transcription factors, epigenetic regulators, and signaling components around MYB suggests a mast cell transcriptional identity/development program activated in UC inflammation.
Genes
Most correlated modules
- Integrin-Calcium Signaling · correlation 0.90
- General Cellular Maintenance · correlation 0.88
- Chromatin & Ubiquitin Regulation · correlation 0.81
- Immune Activation Signaling · correlation 0.79
- Post-transcriptional Regulation · correlation 0.76
- UPR Secretory Stress · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.