Integrin-Calcium Signaling
Gene co-expression module in Mast cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes PIP5K1B (PI(4,5)P2 synthesis, regulates endocytosis and integrin signaling), ITPR2 (IP3 receptor type 2, calcium release from ER), EPS15L1 (endocytic adaptor, clathrin-mediated endocytosis), ITGA4 (integrin alpha-4, mediates mast cell homing to gut via MAdCAM-1/VCAM-1), RALGAPA2 (Ral GTPase activating protein), PCSK5 (proprotein convertase). ITGA4 is critical for mast cell trafficking to the intestinal mucosa. PIP5K1B and ITPR2 link phosphoinositide and calcium signaling. EPS15L1 connects to receptor endocytosis. The module reflects integrin-mediated adhesion and calcium/phosphoinositide signaling relevant to mast cell tissue homing and activation.
Genes
Most correlated modules
- General Cellular Maintenance · correlation 0.92
- Mast Cell Transcription · correlation 0.90
- UPR Secretory Stress · correlation 0.86
- ER-Mitochondria Homeostasis · correlation 0.85
- Immune Activation Signaling · correlation 0.84
- Histone Methylation Regulation · correlation 0.81
- ER & Vesicle Trafficking · correlation 0.80
- Chromatin Epigenetic Regulation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.