General Cellular Maintenance
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 14 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes span diverse housekeeping functions: GNAQ (G-protein signaling), LATS1 (Hippo kinase), HERC2 (ubiquitin E3 ligase), POLD1 (DNA polymerase), TRRAP (chromatin/transcription), SND1 (RNA processing), LPGAT1 (lipid metabolism), ATP6V1C1 (vacuolar ATPase). Uniform expression across subsets, moderate pct positive, and heterogeneous functional categories indicate a broad cellular maintenance/housekeeping program rather than a specific biological pathway. Mild UC inflammation association may reflect general cell activity increase.
Genes
Most correlated modules
- Integrin-Calcium Signaling · correlation 0.92
- ER-Mitochondria Homeostasis · correlation 0.89
- Mast Cell Transcription · correlation 0.88
- Immune Activation Signaling · correlation 0.87
- ER & Vesicle Trafficking · correlation 0.85
- UPR Secretory Stress · correlation 0.85
- Histone Methylation Regulation · correlation 0.85
- Cytoskeletal Organization · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.