Inflammatory Activation
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
TMEM176A and TMEM176B are transmembrane proteins strongly upregulated during inflammation and implicated in NLRP3 inflammasome regulation and mast cell/DC activation. The module has the strongest delta_inflammation_UC signal in this batch (1.016, sig.), indicating robust upregulation in UC inflammation. MYRIP (myosin VIIA/Rab-interacting protein) is involved in secretory granule trafficking. ARPC1B (Arp2/3 complex) drives actin polymerization for degranulation. G0S2 regulates lipid metabolism and cell activation. DPP4 is expressed on activated immune cells. BATF3 is a transcription factor in immune cell differentiation. CST7 (cystatin F) is a lysosomal cysteine protease inhibitor in immune cells. The strong inflammatory upregulation and granule trafficking genes suggest an inflammation-activated mast cell state.
Genes
Most correlated modules
- Mast Cell Identity · correlation 0.79
- Housekeeping Maintenance · correlation 0.66
- Metabolic Redox Stress · correlation 0.63
- Mast Cell Identity · correlation 0.60
- Mast Cell Signaling · correlation 0.57
- Mitochondrial Maintenance · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.