Mast Cell Identity
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 22 genes have a known function matching the annotation |
Why this annotation
Module is anchored by FCER1G (Fc epsilon receptor gamma chain, canonical mast cell marker), HPGDS (hematopoietic prostaglandin D synthase, mast cell-specific eicosanoid enzyme), S100A4/A6/A11 (calcium-binding proteins expressed in mast cells), CSTB (cystatin B, protease inhibitor in granules), LGALS1/3 (galectins), and ATP6V0E1 (vacuolar ATPase for granule acidification). High coherence (all core/strong), 55% positive, mean expression 1.058. This represents a core mast cell identity program with eicosanoid and granule components. Neighbor M50 also has SIGLEC8/LTC4S confirming mast cell identity neighborhood.
Genes
Most correlated modules
- Housekeeping Maintenance · correlation 0.79
- Inflammatory Activation · correlation 0.79
- Actin Cytoskeletal Dynamics · correlation 0.73
- Metabolic Redox Stress · correlation 0.73
- Mitochondrial OxPhos · correlation 0.73
- Mast Cell Identity · correlation 0.72
- Mast Cell Signaling · correlation 0.70
- Mast Cell Signaling · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.