Mast Cell Identity
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 24 genes have a known function matching the annotation |
Why this annotation
Key hub genes: NOP10 (H/ACA snoRNP, rRNA pseudouridylation), SSR4 (signal sequence receptor delta, ER translocation), FCER1A (IgE receptor alpha chain — the defining mast cell surface receptor), HPGD (15-hydroxyprostaglandin dehydrogenase, prostaglandin catabolism), NME1 (nucleoside diphosphate kinase), OSTC (oligosaccharyltransferase complex, N-glycosylation), NKG7 (natural killer granule protein 7, degranulation marker), SEC61G (ER translocon gamma), MYL6 (myosin light chain), SPCS3 (signal peptidase complex), NDUFB2 (Complex I), HDC (histidine decarboxylase — rate-limiting enzyme for histamine biosynthesis), COTL1 (coactosin-like, actin/degranulation). FCER1A + HDC + NKG7 + COTL1 constitute a canonical mast cell identity/degranulation signature. The module is strongly upregulated in UC inflammation (delta=0.674, sig.) and strongly downregulated in remission (delta=-0.920), consistent with mast cell activation in active UC. This is the most biologically specific module in the batch.
Genes
Most correlated modules
- Mitochondrial OxPhos · correlation 0.93
- Mixed Housekeeping · correlation 0.90
- Metabolic Redox Stress · correlation 0.84
- Proteostasis & Translation · correlation 0.80
- Inflammatory Mast Activation · correlation 0.75
- MHC-II Antigen Presentation · correlation 0.74
- Mast Cell Signaling · correlation 0.73
- Actin Cytoskeletal Dynamics · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.