Housekeeping Maintenance
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 18 of 22 genes have a known function matching the annotation |
Why this annotation
This module has high mean expression (0.995) and high detection rate (59.1%), consistent with a housekeeping program. The genes span multiple fundamental cellular processes: CALM1 (calmodulin, calcium signaling), MYL12A/B (myosin light chains, cytoskeletal), NDUFS7 (mitochondrial complex I), SUMO1 (SUMOylation), HMGN1 (chromatin organization), EIF1AX (translation initiation), SRP14 (signal recognition particle), CHMP2A (ESCRT/endosomal sorting), LAMTOR5 (mTORC1 lysosomal signaling), ACSL4 (fatty acid metabolism), DDAH2 (ADMA metabolism), S100A10 (calcium-binding), GUK1 (nucleotide metabolism), PRELID1 (mitochondrial lipid transfer), RASSF5 (Ras effector), EMP3 (membrane protein), CALU (ER calcium-binding), GTF3C6 (transcription factor IIIC), THOC6 (mRNA export). No disease association. This is a broad housekeeping module reflecting constitutive cellular maintenance functions.
Genes
Most correlated modules
- Mast Cell Identity · correlation 0.79
- Proteostasis & Translation · correlation 0.77
- Mast Cell Activation · correlation 0.74
- Protein Biogenesis Housekeeping · correlation 0.72
- Mitochondrial OxPhos · correlation 0.72
- Mast Cell Identity · correlation 0.67
- Inflammatory Activation · correlation 0.66
- Inflammatory Mast Activation · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.