Actin Cytoskeletal Dynamics
Gene co-expression module in Mast cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 31 genes have a known function matching the annotation |
Why this annotation
Hub genes ACTR3 (Arp2/3 complex), PFN1 (profilin, actin polymerization), CFL1 (cofilin, actin depolymerization), ARPC5 (Arp2/3), TPM3 (tropomyosin), CAPG (macrophage capping protein/actin) form a strong actin cytoskeletal core. ENO1, PKM, PGAM1 are glycolytic enzymes. CDK4 is a cell cycle kinase. CCT6A is a chaperonin (assists actin/tubulin folding). COX6B1 and NDUFB11 are mitochondrial. YBX1 is an RNA/DNA binding protein. GSTO1 is glutathione S-transferase omega. PPIA is cyclophilin A (peptidyl-prolyl isomerase). AP2M1 is clathrin adaptor. MTHFD1 is folate metabolism. NCOA4 is a ferritin autophagy receptor. The dominant program is actin cytoskeletal dynamics co-expressed with glycolysis — consistent with cytoskeletal remodeling in mast cells. High mean expression and detection rate support a constitutive program.
Genes
Most correlated modules
- Metabolic Redox Stress · correlation 0.88
- Mitochondrial OxPhos · correlation 0.82
- OxPhos & RNA Processing · correlation 0.77
- Inflammasome Activation · correlation 0.75
- Mast Cell Signaling · correlation 0.75
- MHC-II Antigen Presentation · correlation 0.74
- Mast Cell Identity · correlation 0.73
- Mixed Housekeeping · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.