Inflammasome Activation
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 27 genes have a known function matching the annotation |
Why this annotation
Top hub genes: CDK5 (cyclin-dependent kinase 5, neuronal/immune signaling), DROSHA (microRNA biogenesis), MRE11 (DNA double-strand break repair), HLA-DRB5 and HLA-DRB1 (MHC class II), CASP1 (inflammasome/pyroptosis), RAC1 (Rho GTPase, cytoskeletal/immune signaling), XPO1 (nuclear export), EXOSC8 (RNA exosome), MT1E (metallothionein, stress response), ALDH1A1 (retinoic acid synthesis), PECAM1 (CD31, endothelial/immune adhesion), CALM2 (calmodulin). This is a mixed module combining MHC-II antigen presentation (HLA-DRB1, HLA-DRB5), inflammasome activation (CASP1), DNA repair (MRE11), RNA processing (DROSHA, EXOSC8, XPO1), and stress response (MT1E). The presence of CASP1 and HLA-DR genes alongside CDK5 and RAC1 suggests an inflammatory/activated mast cell state. Neighbor M100 also has HLA-DPA1/DRA, supporting an antigen presentation theme, while CASP1 adds an inflammasome dimension. The module is mixed but the dominant theme is inflammatory activation with antigen presentation.
Genes
Most correlated modules
- MHC-II Antigen Presentation · correlation 0.86
- OxPhos & RNA Processing · correlation 0.83
- Mitotic Spindle · correlation 0.79
- Mitotic Spindle · correlation 0.79
- S-phase DNA Replication · correlation 0.79
- Proliferation RNA Processing · correlation 0.76
- Actin Cytoskeletal Dynamics · correlation 0.75
- Mitotic Spindle · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.