DNA Replication
Gene co-expression module in Mast cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 30 genes have a known function matching the annotation |
Why this annotation
TOPBP1 and RPA1 are core DNA replication initiation/checkpoint factors. CHAF1A (CAF-1 large subunit) deposits histones during DNA replication. NSD2 methylates H3K36 to mark active replication. MBD3 is part of the NuRD repressive chromatin complex. NUP93 and KPNB1 (importin beta) handle nuclear transport. GANAB, STT3A, UGGT1, and SEC61A1 are ER glycosylation/translocation components that co-vary with proliferation (ER expansion). PRMT7 methylates histones/RNA. The module combines DNA replication machinery with ER expansion, both hallmarks of actively proliferating cells.
Genes
Most correlated modules
- FA DNA Repair · correlation 0.91
- S-phase Replication · correlation 0.90
- G2/M Checkpoint · correlation 0.90
- SWI/SNF Remodeling · correlation 0.88
- Chromatin Remodeling · correlation 0.84
- Proliferation RNA Processing · correlation 0.84
- Mitotic Spindle · correlation 0.83
- S-phase DNA Replication · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.