FA DNA Repair
Gene co-expression module in Mast cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes FANCI and FANCD2 define the Fanconi anemia DNA interstrand crosslink repair pathway. BRCA2 is a key FA pathway effector. MCM4 marks DNA replication. PLK4 drives centriole duplication. PRC1, ZWILCH, KNSTRN, CENPU are kinetochore/spindle midzone components. PHF19 is a PRC2 accessory subunit. All genes are core members with uniform expression, consistent with a rare proliferating mast cell subpopulation. The significant UC inflammation delta suggests expansion of proliferating mast cells in inflamed colon.
Genes
Most correlated modules
- S-phase Replication · correlation 0.97
- S-phase DNA Replication · correlation 0.93
- Mitotic Spindle · correlation 0.93
- DNA Replication · correlation 0.91
- Proliferation RNA Processing · correlation 0.88
- G2/M Checkpoint · correlation 0.87
- Chromatin Remodeling · correlation 0.85
- Mitotic Spindle · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.