G2/M Checkpoint
Gene co-expression module in Mast cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes RCC1 (RAN guanine nucleotide exchange factor, mitotic spindle checkpoint), HAUS1 (augmin complex, spindle microtubule nucleation), CDCA4 (cell division cycle associated), CKAP2 (cytoskeleton-associated protein 2, mitotic spindle), USP1 (deubiquitinase in Fanconi/DNA damage), SLFN11 (DNA damage response, replication stress), CASP2 (DNA damage-induced apoptosis), MTFR2 (mitochondrial fission linked to cell cycle) collectively define a G2/M checkpoint and DNA damage response program. Neighbor to M168/M35 (replication) and M91 (spindle/transport), consistent with a checkpoint module bridging replication and mitosis.
Genes
Most correlated modules
- DNA Replication · correlation 0.90
- FA DNA Repair · correlation 0.87
- S-phase Replication · correlation 0.84
- Mitotic Spindle · correlation 0.78
- S-phase Histones · correlation 0.75
- Proliferation RNA Processing · correlation 0.74
- SWI/SNF Remodeling · correlation 0.74
- S-phase DNA Replication · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.