PI3K-Wnt Signaling
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include RAB3GAP1 (RAB3 GTPase activating protein, vesicle trafficking), GET4 (guided entry of tail-anchored proteins, ER membrane targeting), AXIN1 (Wnt pathway scaffold), AKT2 (PI3K/AKT kinase), ATF2 (stress-activated transcription factor), STRN3 (striatin/PP2A complex), LRRFIP2 (innate immune/STING pathway), and TIMM23 (mitochondrial import). No single dominant pathway; the module combines PI3K/AKT/Wnt signaling with vesicle trafficking and ER targeting. AKT2 and AXIN1 together suggest PI3K-Wnt crosstalk as the unifying theme. Low expression and non-significant disease associations suggest a constitutive regulatory program.
Genes
Most correlated modules
- ER Protein Quality Control · correlation 0.92
- Cellular Housekeeping Mixed · correlation 0.89
- Autophagy Lysosomal Program · correlation 0.89
- Inflammatory IRAK3-BATF Response · correlation 0.88
- NF-κB Stress Signaling · correlation 0.86
- RNA & Membrane Housekeeping · correlation 0.84
- Endosomal Trafficking · correlation 0.83
- General Housekeeping · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.