Autophagy Lysosomal Program
Gene co-expression module in Mast cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
ATG14 (autophagy initiation complex), TFE3 (master transcription factor for lysosome biogenesis and autophagy), SLC39A14 (metal transporter regulated by autophagy/lysosome), SLC1A5 (glutamine transporter linked to mTOR/autophagy regulation), ANAPC2 (APC/C, cell cycle and autophagy crosstalk), EDC4 (P-body mRNA decay), and HIPK2 (stress kinase activating autophagy) collectively point to an autophagy and lysosomal biogenesis program. Neighbor M16 shares signaling context. Upregulated in IBD inflammation.
Genes
Most correlated modules
- Circadian Clock Regulation · correlation 0.94
- RAS/Rho GTPase Signaling · correlation 0.93
- Mast Cell Homeostasis · correlation 0.93
- Ubiquitin-Chromatin Regulation · correlation 0.92
- Circadian Transcription · correlation 0.92
- Cellular Housekeeping Mixed · correlation 0.92
- PD-L1 Checkpoint Program · correlation 0.91
- Rho GTPase Signaling · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.