SPP1+ Inflammatory Macrophage
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
SPP1 (osteopontin) is the defining marker of the SPP1+ inflammatory monocyte-derived macrophage subset prominent in IBD. MMP14 drives extracellular matrix remodeling. INHBA (activin A) promotes fibrosis and inflammation. FLT1 (VEGFR1) is expressed on inflammatory myeloid cells. SLC7A11 mediates cystine import for oxidative stress defense. SDC2 and NECTIN2 are cell adhesion/signaling molecules. DUSP4 is a MAPK phosphatase. SLC39A8 is a manganese transporter on macrophages. This module represents the SPP1+ tissue-remodeling inflammatory macrophage program in IBD.
Genes
DOCK4, DUSP4, FLT1, GPR137B, IL7R, INHBA, MMP14, NECTIN2, SDC2, SLAMF1, SLC16A10, SLC39A8, SLC7A11, SPP1, TXN
Most correlated modules
- Tolerogenic Monocyte Activation · correlation 0.87
- NF-κB Counter-regulation · correlation 0.85
- TNF/IL-1 Cytokine Storm · correlation 0.77
- IFN-γ Monocyte Response · correlation 0.71
- Monocyte Tissue Infiltration · correlation 0.71
- NF-κB Signaling · correlation 0.67
- Monocyte Chemokine Secretion · correlation 0.61
- Inflammatory Cell Death · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.