Classical monocyte identity
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 23 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module includes monocyte-associated genes (MS4A14, PLXNC1, CYSLTR2, CHST15, SEC14L1, GPR155, CYRIA, SMAP2, SH3BGRL). Together these suggest a classical monocyte identity/maturation program. Its mixed membership and generic regulators (TUT7, MPHOSPH8, ZNF217) lower confidence.
Genes
Most correlated modules
- Generic transcriptional housekeeping · correlation 0.84
- Nuclear RNA processing · correlation 0.82
- ER-Golgi trafficking · correlation 0.81
- Chromatin regulator transcripts · correlation 0.80
- Myeloid Immunoreceptor Signaling · correlation 0.78
- DNA replication/repair · correlation 0.76
- Leukocyte endothelial adhesion · correlation 0.75
- FOXO1 quiescence program · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.