TNF/IFN co-activation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
BIRC3, SERPINB9, GCH1, NFKBIE, PDE4B, SLAMF7, APOBEC3A and MARCKS are induced by TNF/NF-kB together with interferon. This marks an activated inflammatory monocyte state with anti-apoptotic and cytoprotective features (BIRC3, SERPINB9). The module bridges the M81 NF-kB module and the M4 IFN module, consistent with a mixed IFN plus TNF response.
Genes
Most correlated modules
- IFN-gamma response · correlation 0.83
- Basal endolysosomal maintenance · correlation 0.78
- Type I Interferon · correlation 0.75
- BTN3A immunoregulatory · correlation 0.74
- Myeloid Immunoreceptor Signaling · correlation 0.71
- Inflammatory CXCL10+ monocytes · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.