Transcriptional coregulators
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Members include the transcriptional and chromatin regulators BRD4, CHD8 and TAF2. Nuclear matrix/splicing factors SAFB and ACIN1 are present, together with ubiquitin enzymes UBE2K and UBE3C. All are broadly expressed with uniform distribution. This represents a generic nuclear transcription-regulation housekeeping program, consistent with its neighbors.
Genes
Most correlated modules
- Ubiquitin ligase housekeeping · correlation 0.95
- mRNA splicing machinery · correlation 0.95
- Chromatin repression housekeeping · correlation 0.94
- Long-transcript housekeeping · correlation 0.92
- Translation initiation housekeeping · correlation 0.92
- Microtubule organization · correlation 0.92
- ER secretory housekeeping · correlation 0.92
- Long-gene housekeeping · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.