Inflammatory Autophagy
Gene co-expression module in Monocytes
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes MAP1LC3B (LC3B, core autophagosome marker), ATG2A (autophagy-related lipid transfer), SESN2 (sestrin-2, stress sensor activating autophagy via AMPK/mTOR), TOM1 (endosomal sorting/autophagy), and RABGEF1 (RAB5 GEF, early endosome/autophagy initiation) define a tight autophagy program. RELT (TNF receptor family) links inflammatory signaling to autophagy induction. UPP1 is upregulated under metabolic stress. Module is upregulated in IBD inflammation and reduced in remission, consistent with inflammatory autophagy activation in monocytes.
Genes
ATG2A, MAP1LC3B, RABGEF1, RELT, SESN2, TOM1, UBALD2, UPP1
Most correlated modules
- Endosomal Sorting · correlation 0.86
- AMPK-FOXO Stress Response · correlation 0.83
- Innate Immune Transcription · correlation 0.82
- Autophagy Initiation · correlation 0.81
- MET Tissue Repair · correlation 0.75
- Glucocorticoid Transcription · correlation 0.70
- Secretory Vesicle Trafficking · correlation 0.64
- Hypoxia Response · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.