NF-κB Immune Signaling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include RAPGEF1 and RAPGEF2 (Rap guanine nucleotide exchange factors, downstream of BCR/TCR and integrin signaling), PDE4B (cAMP phosphodiesterase, immune cell signaling), HIVEP1/2 (zinc finger transcription factors that bind NF-κB-like motifs), NFKB1 (NF-κB p50 subunit), SRC (tyrosine kinase), TRAF3 (innate immune/type I IFN signaling adapter), STAP1 (B-cell/pDC signaling adapter), LPXN (leukocyte adhesion/signaling). The convergence of RAPGEF1/2, NFKB1, HIVEP1/2, and TRAF3 suggests a BCR/innate immune NF-κB signaling program relevant to pDCs.
Genes
Most correlated modules
- RNA Processing · correlation 0.88
- Glucocorticoid Receptor · correlation 0.84
- Transcriptional Regulation · correlation 0.84
- pDC Innate Sensing · correlation 0.82
- pDC Activation Response · correlation 0.81
- Chemokine Migration Response · correlation 0.77
- TGF-beta Survival · correlation 0.77
- Autophagy Cytoskeletal · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.