Cell Cycle Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 19 genes have a known function matching the annotation |
Why this annotation
This module has all weak membership genes with uniform expression across subsets and unknown coherence, indicating a poorly defined module. The gene composition is heterogeneous: CDKN1B (p27, cell cycle inhibitor), FANCF (DNA repair/Fanconi anemia), CHMP4B (ESCRT-III, multivesicular body), PAK2 (kinase), FBXO9 (F-box ubiquitin ligase), TXNIP (thioredoxin-interacting, stress/metabolic), HADHA (mitochondrial fatty acid oxidation), SET (chromatin/PP2A inhibitor), RBBP7 (chromatin remodeling), EIF4B (translation), SNRNP27 (splicing). No single coherent biological program dominates. The mix of cell cycle regulation, DNA repair, metabolic, and chromatin genes with all-weak memberships and uniform expression suggests this is a poorly resolved housekeeping/mixed module capturing general cellular maintenance functions. The neighbor context (other modules in this batch are similarly weak/uniform) supports a technical or housekeeping interpretation rather than a specific biological program.
Genes
Most correlated modules
- Transcriptional Regulation · correlation 0.92
- ER Protein Folding · correlation 0.92
- DNA Repair & Chromatin · correlation 0.91
- Monocyte Chemotaxis · correlation 0.89
- Endosomal Trafficking · correlation 0.88
- IFN Receptor Signaling · correlation 0.87
- RNA Processing · correlation 0.85
- Mixed Regulatory · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.