Endosomal Trafficking
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 25 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression, with unknown coherence. Hub genes include VPS4B (AAA-ATPase, ESCRT-III disassembly/vesicular trafficking), SNX1 (sorting nexin, endosomal trafficking), KTN1 (kinectin, ER-vesicle tethering), HPS3/HPS4 (Hermansky-Pudlak syndrome, lysosome-related organelle biogenesis), PIGS (GPI anchor biosynthesis), LCP1 (actin bundling), TLN1 (talin, focal adhesion/cytoskeletal), VCL (vinculin, cytoskeletal), SUZ12 (PRC2 chromatin), SAMHD1 (dNTPase, antiviral/DNA repair), LRPPRC (mitochondrial RNA processing). The strongest theme is vesicular/endosomal trafficking (VPS4B, SNX1, KTN1, HPS3, HPS4, PIGS), with cytoskeletal and chromatin genes as secondary components. The HPS3/HPS4 pairing is notable for lysosome-related organelle biogenesis. Given the neighbor context of similarly weak/mixed modules, this likely represents a loosely co-expressed housekeeping program centered on vesicular trafficking.
Genes
Most correlated modules
- Transcriptional Regulation · correlation 0.93
- DNA Repair & Chromatin · correlation 0.92
- Cell Cycle Regulation · correlation 0.88
- IFN Receptor Signaling · correlation 0.88
- ER Quality Control · correlation 0.87
- Monocyte Chemotaxis · correlation 0.87
- ER Protein Folding · correlation 0.85
- RNA Processing · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.