Transcriptional Repression
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
This module has weak coherence with all genes showing weak membership and uniform expression across subsets. Hub genes include SBDS (ribosome biogenesis), CBX4 (Polycomb repression), TOB1 (anti-proliferative mRNA regulation), KLF10 (TGF-beta response transcription factor), HEXIM1 (P-TEFb inhibitor suppressing transcription elongation), and ID1 (BMP/TGF-beta target). Several genes converge on transcriptional repression and anti-proliferative signaling (TOB1, KLF10, HEXIM1, CBX4, ID1), suggesting a loose growth-arrest or transcriptional repression program, but the module is poorly defined with mixed functions including RNA metabolism (DDX3X, EIF1, SBDS) and signaling (MAP3K8, ARL4C, ARL4A).
Genes
Most correlated modules
- Autophagy Cytoskeletal · correlation 0.86
- RNA Processing · correlation 0.79
- TGF-beta Survival · correlation 0.79
- Chemokine Migration Response · correlation 0.76
- Glucocorticoid Stress Response · correlation 0.75
- RNA Splicing Regulation · correlation 0.69
- pDC Activation Response · correlation 0.68
- Stress & Apoptotic Priming · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.