Mixed Regulatory
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 23 genes have a known function matching the annotation |
Why this annotation
TRAF3IP3 (TRAF3-interacting protein 3) is involved in innate immune signaling and regulation of type I IFN production — directly relevant to pDC biology. SCML2 is a Polycomb group protein. SUGT1 (kinetochore assembly). PLRG1 (pre-mRNA splicing). ST3GAL2 (sialyltransferase, glycosylation). SEPHS2 (selenophosphate synthetase). The module is highly mixed with no dominant coherent theme. TRAF3IP3 is the most biologically relevant gene for pDCs. The module likely represents a weakly co-expressed set of housekeeping/regulatory genes.
Genes
Most correlated modules
- Transcriptional Regulation · correlation 0.88
- Monocyte Chemotaxis · correlation 0.88
- IFN Receptor Signaling · correlation 0.86
- Cell Cycle Regulation · correlation 0.85
- Immune Cell Migration · correlation 0.82
- Metabolic Housekeeping · correlation 0.82
- Epigenetic Silencing · correlation 0.79
- pDC Identity · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.