Ribosome Biogenesis
Gene co-expression module in Plasma cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes TCOF1 (rDNA transcription/ribosome biogenesis), LTV1 (40S ribosome assembly), DRG1 (60S ribosome assembly), DDX54 (pre-rRNA processing helicase), and IARS2 (mitochondrial tRNA synthetase supporting translation) collectively point to a ribosome biogenesis and translational capacity program. MRPS23 (mitochondrial ribosomal protein) further supports active translation. The module is enriched in plasmablasts (2-6x), consistent with the high biosynthetic demands of antibody-secreting cells. Upregulation with inflammation and downregulation with treatment fits a plasmablast activation state. Module coherence is moderate with many weak-membership genes, indicating a mixed but biologically coherent core around ribosome biogenesis.
Genes
Most correlated modules
- Plasmablast Stress Activation · correlation 0.95
- Plasmablast Apoptosis · correlation 0.95
- Nuclear Transport Chromatin · correlation 0.94
- Nuclear Export Replication · correlation 0.94
- Plasmablast Proliferation · correlation 0.94
- Chromatin Remodeling · correlation 0.93
- Plasmablast Trafficking · correlation 0.92
- Plasmablast Differentiation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.