Nuclear Transport Chromatin
Gene co-expression module in Plasma cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
Moderate coherence module strongly enriched in plasmablasts. Hub genes BAZ1B (ISWI chromatin remodeling), PRKDC (DNA-PKcs, DNA double-strand break repair and V(D)J/class switch recombination), SF3B2 (spliceosome SF3b complex), KPNB1 (importin beta-1, nuclear import), PRPF40A (splicing factor), SUZ12 (PRC2 Polycomb repressor), CTCF (chromatin insulator/organizer), SRRM1 (serine/arginine splicing), XPO1 (CRM1 nuclear export), IPO5 (importin 5), ILF3 (NF90, RNA binding/nuclear transport). This module reflects active nuclear transport, chromatin remodeling, and splicing regulation in plasmablasts — consistent with the massive transcriptional reprogramming during plasma cell differentiation. PRKDC's high plasmablast enrichment may reflect class switch recombination.
Genes
Most correlated modules
- Nuclear Export Replication · correlation 0.97
- RNA Splicing Processing · correlation 0.97
- Plasmablast Stress Activation · correlation 0.97
- Polyamine Biosynthesis · correlation 0.96
- Plasmablast Apoptosis · correlation 0.96
- Plasmablast Proliferation · correlation 0.96
- Plasmablast Trafficking · correlation 0.95
- Housekeeping Mixed · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.