ER Secretory Expansion
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
DNAJC10 (ER-resident DnaJ/Hsp40, ERAD), EDEM1 (ER degradation enhancer, ERAD), ERGIC1 (ER-Golgi intermediate compartment), GANAB (glucosidase II alpha, N-glycosylation quality control), STT3B (oligosaccharyltransferase catalytic subunit), AP3D1 (AP-3 adaptor, vesicle trafficking), YKT6 (SNARE protein, vesicle fusion), TM9SF3 (nonaspanin, membrane trafficking) collectively define ER/secretory pathway expansion. POU2AF1 (OBF-1, B cell co-activator) and CD79B (Igβ, BCR signaling) confirm B cell/plasmablast identity. This ER expansion program supports high-level immunoglobulin secretion. Strong inflammation association.
Genes
Most correlated modules
- N-glycosylation ER · correlation 0.95
- ER Protein Folding · correlation 0.94
- Nuclear Export Replication · correlation 0.93
- Polyamine Biosynthesis · correlation 0.93
- ER-Golgi Secretory Pathway · correlation 0.92
- Plasmablast Differentiation · correlation 0.92
- COPI Vesicle Trafficking · correlation 0.91
- Plasmablast Proliferation · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.