Heat Shock Response
Gene co-expression module in Plasma cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes DNAJB1, HSPH1, HSPA1A, BAG3, HSPB1, HSPA6, DNAJA1, DNAJB4 are all canonical heat shock proteins and co-chaperones (HSP70/HSP40/HSP110 family). ZFAND2A is a stress-induced ubiquitin-binding protein. GADD45B and IER5 are stress-response genes. The module is strongly coherent, enriched in igA_plasma, suppressed during inflammation, and restored in UC remission — consistent with a proteostasis stress program active in healthy plasma cells that is disrupted during inflammatory disease. Neighbor M91 covers the UPR/ER stress arm, while M48 covers the cytoplasmic chaperone arm of the heat shock response.
Genes
Most correlated modules
- AP-1 Immediate Early · correlation 0.89
- Stress-induced Quiescence · correlation 0.88
- Immediate Early TFs · correlation 0.87
- Glucocorticoid Response · correlation 0.77
- ER Stress UPR · correlation 0.63
- Tissue Residency Activation · correlation 0.63
- Chaperone Proteostasis · correlation 0.61
- IgA Plasma Maturation · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.