Stress-induced Quiescence
Gene co-expression module in Plasma cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
This module has moderate coherence with many weak-membership genes. IER3 is an immediate-early response gene; HSPA1L is a heat shock protein (linking to neighbor M48); ZC3H12A (MCPIP1) is an anti-inflammatory mRNA endonuclease; CDKN1C (p57/KIP2) is a CDK inhibitor; SERTAD1 is involved in cell cycle and stress; RASD1 is a stress-induced small GTPase; RRAD is a stress/metabolic gene; TSPYL2 is a nucleosome assembly/stress gene; INTS6 is an Integrator complex subunit. IL23A is notable but weakly associated. The module appears to represent a mixed stress-response and cell cycle arrest program, consistent with plasma cell quiescence under stress. Suppressed in inflammation, restored in UC remission.
Genes
Most correlated modules
- Heat Shock Response · correlation 0.88
- Immediate Early TFs · correlation 0.86
- AP-1 Immediate Early · correlation 0.78
- Glucocorticoid Response · correlation 0.66
- Chaperone Proteostasis · correlation 0.57
- IgA Plasma Maturation · correlation 0.54
- ER Stress UPR · correlation 0.54
- Tissue Residency Activation · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.