Glucocorticoid Response
Gene co-expression module in Plasma cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 26 genes have a known function matching the annotation |
Why this annotation
TSC22D3 (GILZ) is a canonical glucocorticoid-induced leucine zipper protein and a key mediator of glucocorticoid anti-inflammatory effects. TXNIP is a metabolic stress/thioredoxin-interacting protein. ZFP36L2 regulates mRNA stability. MCL1 is an anti-apoptotic BCL2 family member. BTG1 is anti-proliferative. DUSP5 is a stress-induced phosphatase. CSRNP1 is a stress-response TF. PPP1R15B (CReP) regulates eIF2alpha phosphatase. RGCC regulates cell cycle. CD55 is a complement regulatory protein. CCNL1 is a cyclin. The uniform expression across subsets and the presence of TSC22D3/GILZ as a hub gene, alongside anti-proliferative and mRNA stability genes, suggests a glucocorticoid-response / anti-proliferative program. Neighbor to M46 (AP-1/stress) and M33 (quiescence).
Genes
Most correlated modules
- AP-1 Immediate Early · correlation 0.90
- Tissue Residency Activation · correlation 0.87
- Immediate Early TFs · correlation 0.84
- Heat Shock Response · correlation 0.77
- Stress-induced Quiescence · correlation 0.66
- ER Stress UPR · correlation 0.63
- Chaperone Proteostasis · correlation 0.47
- IgA Plasma Maturation · correlation 0.41
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.