Immediate Early TFs
Gene co-expression module in Plasma cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes KDM6B (H3K27me3 demethylase, epigenetic stress/inflammatory regulator), MAFF (stress-responsive bZIP TF), DUSP2 (MAP kinase phosphatase), ZBTB10 (transcriptional repressor), MXD1 (MYC antagonist bHLH TF), EGR3, and EGR2 (early growth response TFs critical for plasma cell differentiation and stress response) form a coherent module of immediate-early transcription factors. EGR2/EGR3 are also key regulators of plasma cell identity. The module is suppressed in inflammation and restored in UC remission. Neighbor to M46 (AP-1/IEG) and M48 (HSP), supporting a coordinated immediate-early transcriptional stress response in igA plasma cells.
Genes
Most correlated modules
- Heat Shock Response · correlation 0.87
- AP-1 Immediate Early · correlation 0.86
- Stress-induced Quiescence · correlation 0.86
- Glucocorticoid Response · correlation 0.84
- Tissue Residency Activation · correlation 0.69
- Chaperone Proteostasis · correlation 0.55
- ER Stress UPR · correlation 0.54
- IgA Plasma Maturation · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.