Ubiquitin-like Modification
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 7 genes have a known function matching the annotation |
Why this annotation
The module is anchored by RHOA (Rho GTPase) but the majority of genes encode ubiquitin-like post-translational modification machinery: NEDD8 (neddylation), SUMO2 (SUMOylation), UBE2D2 (ubiquitin E2 conjugating enzyme), PSME1 (proteasome activator PA28α). VDAC2 links to mitochondria (neighbor M78), and SRSF9 is a splicing factor. The core program is ubiquitin/SUMO/NEDD8-mediated protein modification and proteasomal activation, which is critical for plasmablast immunoglobulin quality control and cell signaling. Strong coherence supports a unified program.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.98
- Mitochondrial Respiration · correlation 0.97
- Protein Quality Control · correlation 0.97
- Oxidative Phosphorylation · correlation 0.97
- Proteasome Activity · correlation 0.96
- OxPhos & Proteasome · correlation 0.96
- Mitochondrial OxPhos · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.