Protein Quality Control
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
The top hub gene PSMA5 (proteasome alpha-5 subunit) anchors a protein quality control program. CCT8 (chaperonin TRiC/CCT subunit 8) is a major chaperone for protein folding. EIF2S2 (eIF2 beta) is a translation initiation factor. ELOC (elongin C) is part of a ubiquitin E3 ligase complex. RTRAF (RNA transcription and translation factor) links transcription to translation. ERH (enhancer of rudimentary homolog) participates in pyrimidine metabolism and pre-mRNA splicing. SF3B6 (splicing factor 3B subunit 6) adds splicing. Mitochondrial components include VDAC3, MRPS16, NDUFA12, GHITM, SSBP1. The proteasome + chaperonin + translation initiation combination defines a protein quality control/proteostasis program, distinct from M32 (which emphasizes proteasome ATPase/regulatory subunits) by focusing on alpha subunits and chaperonin-assisted folding. Neighbor M32 shares proteasome identity, confirming this as a proteostasis neighborhood.
Genes
Most correlated modules
- Proteasome Activity · correlation 0.98
- Oxidative Phosphorylation · correlation 0.98
- Mitochondrial Respiration · correlation 0.97
- Glycolytic Reprogramming · correlation 0.97
- Oxidative Phosphorylation · correlation 0.97
- Ubiquitin-like Modification · correlation 0.97
- OxPhos & Proteasome · correlation 0.97
- RNA Splicing & Glycolysis · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.