Oxidative Phosphorylation
Gene co-expression module in Plasma cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
The module contains multiple ATP synthase subunits (ATP5PF, ATP5F1C, ATP5F1B — F1Fo ATP synthase components), NADH dehydrogenase subunits (NDUFA4, NDUFAB1, NDUFB2 — Complex I), and COX5A (Complex IV cytochrome c oxidase). These define a clear oxidative phosphorylation program. POMP (proteasome maturation protein) and PSMB1 (proteasome beta-1) add protein quality control. ARPC2/ARPC3 (Arp2/3) add cytoskeletal elements shared with M14 and M88. SRP14 (signal recognition particle) and FKBP1A (immunophilin) are peripheral. The OxPhos genes are the most numerous and coherent cluster. This module shows the strongest inflammation association (delta_inflammation 0.879, sig.), suggesting OxPhos upregulation during active plasmablast expansion in IBD. Neighbors M8 and M88 also contain OxPhos genes, forming a metabolic neighborhood.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.98
- Mitochondrial Respiration · correlation 0.98
- Protein Quality Control · correlation 0.98
- Ubiquitin-like Modification · correlation 0.98
- OxPhos & Proteasome · correlation 0.97
- Proteasome Activity · correlation 0.97
- Glycolytic Reprogramming · correlation 0.96
- RNA Splicing & Glycolysis · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.