Cobalamin Uptake Program
Gene co-expression module in Tuft cells
| Category | Cehmical sensing |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
The module is dominated by AMN and CD320, which together form the cubilin-amnionless receptor complex responsible for intestinal cobalamin (vitamin B12) uptake. Supporting genes include CFTR and KCNE3 (ion transport characteristic of intestinal secretory lineages), SRM (polyamine biosynthesis), CKMT1B (mitochondrial creatine kinase), LCN2 (lipid/iron transport), ST6GAL1 (sialylation), ALG3 (N-glycosylation), MARCKS (membrane differentiation signaling), CAMK1D (calcium signaling), MCM4 (minor proliferative), and NDRG2 (differentiation). All genes are strongly enriched in pre_tuft cells. The dominant biological program is cobalamin/B12 metabolic uptake combined with ion transport, representing a metabolic specialization program active in pre-tuft progenitors transitioning toward mature tuft identity.
Genes
Most correlated modules
- Progenitor Cell Proliferation · correlation 0.98
- Metallothionein Stress Response · correlation 0.97
- Epithelial Progenitor Differentiation · correlation 0.97
- Secretory Progenitor Commitment · correlation 0.95
- Ribosome Biogenesis · correlation 0.95
- Proliferating Mucus Secretory · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.