Proliferating Mucus Secretory
Gene co-expression module in Tuft cells
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
MKI67 (Ki-67, proliferation marker), HELLS (helicase lymphoid-specific, chromatin remodeling during replication), MUC5B/MUC12/MUC4 (mucins, secretory lineage), CDHR1 (cadherin-related family member, photoreceptor/intestinal), PHGR1 (proline/histidine/glycine-rich 1, intestinal secretory), ERN2 (IRE1-beta, UPR sensor in secretory intestinal cells), SLC26A2 (sulfate transporter, colonocyte), GGT6 (gamma-glutamyltransferase), PCK1 (PEPCK, gluconeogenesis/metabolic). MKI67 and HELLS confirm active proliferation; MUC5B/MUC12/MUC4 and ERN2 indicate secretory mucin-producing lineage commitment with UPR activation. This module captures a proliferating mucus-secretory progenitor state.
Genes
Most correlated modules
- G2/M Progenitor Proliferation · correlation 0.99
- Secretory Progenitor Commitment · correlation 0.97
- Progenitor S-phase · correlation 0.97
- Epithelial Progenitor Differentiation · correlation 0.96
- Pre-tuft WNT Secretion · correlation 0.95
- Progenitor Metabolic Reprogramming · correlation 0.95
- Pre-tuft Differentiation · correlation 0.93
- Cobalamin Uptake Program · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.