Secretory Progenitor Commitment
Gene co-expression module in Tuft cells
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
AGR2 (anterior gradient 2, canonical secretory/goblet cell ER chaperone), TSPAN8 (tetraspanin, intestinal secretory lineage), FAM3D (intestinal secreted cytokine), PLA2G2A (secreted phospholipase A2, Paneth/secretory cells), HMGCS2 (ketogenesis enzyme, colonocyte differentiation), RARRES2 (chemerin, secreted), GOLM1 (Golgi membrane, secretory trafficking), TK1 (thymidine kinase, proliferation), CDC42EP5 (Cdc42 effector), CHP2 (calcineurin homolog, ion transport), CES2 (carboxylesterase, absorptive/secretory), DBI (diazepam binding inhibitor, lipid metabolism). This module strongly resembles a secretory progenitor program, with AGR2/TSPAN8/FAM3D/PLA2G2A pointing to goblet/secretory lineage commitment in pre-tuft cells.
Genes
Most correlated modules
- Progenitor S-phase · correlation 1.00
- Metallothionein Stress Response · correlation 0.99
- Precursor Cell Cycle · correlation 0.99
- Prostaglandin Biosynthesis · correlation 0.99
- G2/M Progenitor Proliferation · correlation 0.98
- Epithelial Progenitor Differentiation · correlation 0.98
- Glycolytic TCA Metabolism · correlation 0.98
- Pre-tuft WNT Secretion · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.