Ribosome Biogenesis
Gene co-expression module in Tuft cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes NOLC1 (nucleolar phosphoprotein, rRNA processing), GNL3 (nucleolar GTPase essential for ribosome biogenesis), RSL1D1 (ribosomal large subunit biogenesis), and NHP2-related NOP family members collectively define a ribosome biogenesis program. TOMM20 and GRPEL1 support mitochondrial protein import and chaperone activity. ALYREF mediates mRNA nuclear export. SEC11A is a signal peptidase. PSMG1 is a proteasome assembly chaperone. RAB32 and NECTIN3 are involved in vesicle trafficking and cell adhesion respectively. The dominant theme is nucleolar ribosome biogenesis (NOLC1, GNL3, RSL1D1) combined with mitochondrial import machinery, characteristic of biosynthetically active pre_tuft progenitors. Neighbor context: complements M60 (translation initiation) and M55 (mitotic/RNA processing) in the same pre_tuft proliferative program.
Genes
Most correlated modules
- Epithelial Progenitor Differentiation · correlation 0.99
- Precursor Cell Cycle · correlation 0.98
- Metallothionein Stress Response · correlation 0.98
- Progenitor Cell Proliferation · correlation 0.98
- Mitotic Spindle Assembly · correlation 0.98
- Translation Initiation · correlation 0.97
- Progenitor S-phase · correlation 0.95
- Pre-tuft WNT Secretion · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.